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Article

IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence.

Journal of cell science - 15 Aug 2013

Alexander Eva, Hildebrand Dominic G, Kriebs Anna, Obermayer Kerstin, Manz Marianne, Rothfuss Oliver, Schulze-Osthoff Klaus, Essmann Frank

Abstract excerpt

Cellular senescence, a state of sustained cell cycle arrest, has been identified as an important anti-tumor barrier. Senescent cells secrete various growth factors and cytokines, such as IL6 and IL8, which collectively constitute the senescence-associated secretory phenotype (SASP). The SASP can...

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Identifiers

PMID: 23781024
DOI: 10.1242/jcs.128835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23781024-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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