Article

Identifying NAHR mechanism between two distinct Alu elements through breakpoint junction mapping by NGS

2020-01-08

Abstract excerpt

<title>Abstract</title> <p>Background: Genomic rearrangements encompass deletions, duplications, inversions, insertions and translocations and may be the cause of several genetic diseases. One of the most frequent mechanisms that generates these rearrangements is the Non-Allelic Homologous Recombination (NAHR). They are caused by a misalignment between regions of high level of similarity, like Low Copy Repeats (L...

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Literature Corpus work: 83207c7d-7f91-51ab-bc04-34bcf7fae60b
DOI: 10.21203/rs.2.20329/v1

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