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Article

Origins and breakpoint analyses of copy number variations: up close and personal.

Cytogenetic and genome research - 1 Jan 2011

van Binsbergen E

Abstract excerpt

Array-based methods have enabled the detection of many genomic gains and losses. These are stated as copy number variants (CNVs) and comprise up to 13% of the human genome. Based on their breakpoints and modes of formation CNVs are termed recurrent or nonrecurrent. Recurrent CNVs are flanked by low copy repeats and are of a fixed size. They arise as a result of misalignment during meiosis by a mechanism named...

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PMID: 21846967
DOI: 10.1159/000330267

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