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Article

Detecting non-allelic homologous recombination from high-throughput sequencing data.

Genome biology - 8 Apr 2015

Parks Matthew M, Lawrence Charles E, Raphael Benjamin J

Abstract excerpt

Non-allelic homologous recombination (NAHR) is a common mechanism for generating genome rearrangements and is implicated in numerous genetic disorders, but its detection in high-throughput sequencing data poses a serious challenge. We present a probabilistic model of NAHR and demonstrate its ability to find NAHR in low-coverage sequencing data from 44 individuals. We identify NAHR-mediated deletions or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25886137
DOI: 10.1186/s13059-015-0633-1
PMCID: PMC4425883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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