Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomes.

doi:10.1101/gr.111609.110

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Article

Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomes.

Genome research - 1 Jan 2011

Ou Zhishuo, Stankiewicz Paweł, Xia Zhilian, Breman Amy M, Dawson Brian, Wiszniewska Joanna, Szafranski Przemyslaw, Cooper M Lance, Rao Mitchell, Shao Lina, South Sarah T, Coleman Karlene, Fernhoff Paul M, Deray Marcel J, Rosengren Sally, Roeder Elizabeth R, Enciso Victoria B, Chinault A Craig, Patel Ankita, Kang Sung-Hae L, Shaw Chad A, Lupski James R, Cheung Sau W

Abstract excerpt

Four unrelated families with the same unbalanced translocation der(4)t(4;11)(p16.2;p15.4) were analyzed. Both of the breakpoint regions in 4p16.2 and 11p15.4 were narrowed to large ∼359-kb and ∼215-kb low-copy repeat (LCR) clusters, respectively, by aCGH and SNP array analyses. DNA sequencing enabled mapping the breakpoints of one translocation to 24 bp within interchromosomal paralogous LCRs of ∼130 kb in length...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21205869
DOI: 10.1101/gr.111609.110
PMCID: PMC3012924

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