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To Detach, Migrate, Adhere, and Metastasize: CD97/ADGRE5 in Cancer

4 May 2022

Abstract excerpt

Tumorigenesis is a multistep process, during which cells acquire a series of mutations that lead to unrestrained cell growth and proliferation, inhibition of cell differentiation, and evasion of cell death. Growing tumors stimulate angiogenesis, providing them with nutrients and oxygen. Ultimately, tumor cells invade the surrounding tissue and metastasize; a process responsible for about 90% of cancer-related...

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PMID: 35563846
DOI: 10.3390/cells11091538

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