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Article

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease.

Annual review of immunology - 26 Apr 2018

Uhlig Holm H, Powrie Fiona

Abstract excerpt

Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and epigenetic susceptibility impact on immune pathways is key for developing targeted therapies. Mechanistic understanding of polygenic IBD is complemented by Mendelian disorders that present with IBD, pharmacological interventions that...

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PMID: 29677472
DOI: 10.1146/annurev-immunol-042617-053055

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