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Systemic Citrate Toxicity During Regional Citrate Anticoagulation for Continuous Kidney Replacement Therapy

2026-07-03

Abstract excerpt

<h4>Background: </h4> Regional citrate anticoagulation (RCA) is the recommended anticoagulation strategy for continuous kidney replacement therapy (CKRT) because it prolongs circuit lifespan and reduces bleeding risk compared with systemic heparin. However, systemic citrate accumulation may occur when citrate delivery exceeds metabolic or extracorporeal clearance, potentially leading to severe metabolic disturbanc...

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Literature Corpus work
bc39f71d-e097-519e-ba4e-dddb56c5fc0f
DOI
10.20944/preprints202607.0291.v1
Open publication

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Systemic Citrate Toxicity During Regional Citrate Anticoagulation for Continuous Kidney Replacement TherapyDOI 10.20944/preprints202607.0291.v1
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