Article

The Multi-Omic Transformation of Breast Cancer Diagnostics: A Comprehensive Review of the Transition from Immunohistochemistry to Liquid Biopsy and Next-Generation Sequencing

2026-02-09

Abstract excerpt

<h4>Background: </h4> Breast cancer (BC) diagnostics are undergoing a transformative shift from traditional morphological assessment to a complex multi-omic characterization. While Immunohistochemistry (IHC) remains the clinical bedrock for subtyping, its inherent inability to account for intra-tumoral heterogeneity and the dynamic nature of clonal evolution has necessitated the integration of high-throughput geno...

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Literature Corpus work: e793df97-3a07-5abd-a1c2-6005eda3f466
DOI: 10.20944/preprints202602.0664.v1

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