Article

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

2023-03-02

Abstract excerpt

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate succinate uptake in these adipocytes remain undefined. Here we elucidate a mechanism underlying succinate import into BAT via monocarboxylate transporters (MCTs). We show that s...

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Literature Corpus work: 82ce8011-2f3c-599c-bf61-418f4ceae7ff
DOI: 10.1101/2023.03.01.530625

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