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Article

Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosis

2024-11-15

Abstract excerpt

<h4>Introduction</h4> Focal segmental glomerulosclerosis (FSGS) is a significant cause of chronic kidney disease and triggered by podocyte damage which can result in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alters cytoskeletal microtubules and has been used clinically to reverse FSGS. However, the mechanisms underlying the beneficial effect of vincri...

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Literature Corpus work
829c74b2-6ea1-5d18-acad-5cfd7d4961ea
DOI
10.1101/2024.11.13.623397
Open publication

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Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosisDOI 10.1101/2024.11.13.623397
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