Article

Deciphering the Genetic Basis of Focal Segmental Glomerulosclerosis Using Next-Generation Sequencing

2026-05-25

Abstract excerpt

<title>Abstract</title> <p> Introduction: Focal Segmental Glomerulosclerosis (FSGS) is a heterogeneous glomerular disorder characterized by segmental sclerosis of one or more glomeruli and prominent proteinuria. Podocyte injury underlies the pathogenesis and compromises the renal filtration barrier. FSGS can be classified into primary, genetic, and secondary forms, with secondary causes including maladaptive, i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 43504640-642a-5de2-9ce0-8e7d36b3a945
DOI: 10.21203/rs.3.rs-9779255/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering the Genetic Basis of Focal Segmental Glomerulosclerosis Using Next-Generation SequencingDOI 10.21203/rs.3.rs-9779255/v1Read

Targeted NGS panel reveals a high burden of collagen IV, podocyte, and transcription factor gene mutations in biopsy-proven focal segmental glomerulosclerosisSemantic proximity Read

A Simple Tool to Predict Genetic Focal Segmental GlomerulosclerosisSemantic proximity Read

Advances in molecular diagnosis and therapeutics in nephrotic syndrome and focal and segmental glomerulosclerosis.Semantic proximity Read

COL4A3 mutations cause focal segmental glomerulosclerosis.Semantic proximity Read

Next-generation sequencing in patients with familial FSGS: first report of collagen gene mutations in Tunisian patients.Semantic proximity Read

A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic AssociationsSemantic proximity Read

Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing.Semantic proximity Read

Collagen (COL4A) mutations are the most frequent mutations underlying adult focal segmental glomerulosclerosis.Semantic proximity Read

Targeted next-generation sequencing in steroid-resistant nephrotic syndrome: mutations in multiple glomerular genes may influence disease severity.Semantic proximity Read

LAMA2 and LOXL4 Are Candidate FSGS GenesSemantic proximity Read

Nephrotic syndrome genomic discovery in the Mass General Brigham Biobank identifies monoallelic MEFV variants as a risk factor for focal segmental glomerulosclerosis.Semantic proximity Read

Genetic Causes of Nephrotic Syndrome and Focal and Segmental Glomerulosclerosis.Semantic proximity Read