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Beyond T3: The Emerging Role of 3,5-Diiodothyronine in Mitochondrial Thyroid Hormone Signaling

2026-06-30

Abstract excerpt

Thyroid hormone physiology has traditionally been interpreted through the hypothalamic–pituitary–thyroid (HPT) axis and genomic signaling mediated by triiodothyronine (T3). However, accumulating evidence indicates that thyroid hormone action extends beyond classical nuclear receptor pathways and involves rapid, non-genomic mechanisms that influence cellular metabolism. Among the metabolites generated during thyroi...

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Literature Corpus work
57abfb0e-76cc-53f2-98ed-462965dd3384
DOI
10.20944/preprints202606.2262.v1
Open publication

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