Article

BMP4 patterns Smad activity and generates stereotyped cell fate organisation in spinal organoids

2019-01-04

Abstract excerpt

Bone Morphogenetic Proteins (BMP) are secreted regulators of cell fate in several developing tissues. In the embryonic spinal cord, they control the emergence of the neural crest, roof plate and distinct subsets of dorsal interneurons. Although a gradient of BMP activity has been proposed to determine cell type identity in vivo , whether this is sufficient for pattern formation in vitro is unclear. Here, we demo...

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Literature Corpus work: 8285297b-1da3-5a2a-98fd-b12ace2a5d4f
DOI: 10.1101/511899

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