Article

HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in familial and sporadic amyotrophic lateral sclerosis models

2023-09-07

Abstract excerpt

<title>Abstract</title> Early defects at the neuromuscular junction (NMJ) are among the first hallmarks of the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). According to the “dying back” hypothesis, disruption of the NMJ not only precedes, but is also a trigger for the subsequent degeneration of the motoneuron. However, the pathogenic mechanisms linking genetic and environmental fa...

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Literature Corpus work: 290fc597-16a7-5846-9ab4-fae2ac5a27c2
DOI: 10.21203/rs.3.rs-3200249/v1

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