Article

Microglia undergoes chemokine receptor, CX3CR1-mediated internalization of extracellular Tau

2024-12-04

Abstract excerpt

In Alzheimer’s disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. CX3CR1 receptor is involved in monomeric Tau internalization by directly binding to the receptor. In our study, we are interested in understanding the interaction of different pathological structures of Tau with microglial chemokine receptor, CX3CR1 and...

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Identifiers and source

Literature Corpus work: 8258e1b0-f220-575d-a52d-a9054857f35b
DOI: 10.1101/2024.12.03.626734

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