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Article

CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Zhang Xiao-Fang, Zhao Yan-Feng, Zhu Shun-Wei, Huang Wei-Jie, Luo Yan, Chen Qing-Ying, Ge Li-Jun, Li Run-Sheng, Wang Jian-Fei, Sun Mu, Xiao Zhi-Cheng, Fan Guo-Huang

Abstract excerpt

Truncation of tau protein is considered an early event in Alzheimer's disease (AD) and is believed to play a major pathogenic role in sporadic AD. However, causative factors that trigger tau truncation in AD remain poorly understood. In the present study, we demonstrate that CXCL1 (C-X-C motif ligand 1), a specific ligand for the chemokine receptor CXCR2, induced cleavage of tau at ASP421 in a caspase-3-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26401931
DOI: 10.3233/JAD-150041

Genes

CXCL1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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