Article

Effects of 5-aza-2'-deoxycytidine on DNA Methylation within Female Mouse Reproductive Tissues

2022-10-04

Abstract excerpt

<title>Abstract</title> <p>5-aza-2'-deoxycytidine (decitabine), is a chemotherapeutic DNA methyltransferase (DNMT) inhibitor widely used to treat myelodysplastic syndrome and acute myeloid leukemias. Decitabine’s anti-neoplastic activity is thought to result from inhibition of DNMTs leading to passive demethylation of 5’methylcytosines (5mC) in rapidly dividing tissues, resulting in cell death. However, we previo...

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Literature Corpus work: 824e54dd-84ed-59dd-98ed-0c7c114233d5
DOI: 10.21203/rs.3.rs-1547192/v3

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