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Article

Effects of 5-Aza-2′-deoxycytidine (decitabine) on gene expression

18 Feb 2018

Abstract excerpt

5-Aza-2'-deoxycytidine (AzaD), also known as Decitabine, is a deoxycytidine analog that is typically used to activate methylated and silenced genes by promoter demethylation. However, a survey of the scientific literature indicates that promoter demethylation may not be the only (or, indeed, the major) mechanism by which AzaD affects gene expression. Regulation of gene expression by AzaD can occur in several...

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PMID: 29455551
DOI: 10.1080/03602532.2018.1437446

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