Article

Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh Syndrome

2024-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Deficits in the mitochondrial energy-generating machinery cause mitochondrial disease (MD), a group of untreatable and usually fatal disorders. Among many severe symptoms, refractory epileptic events are a common neurological presentation of MD. However, the neuronal substrates and circuits for MD-induced epilepsy remain unclear. Here, using mouse models of mitochondrial epilepsy that lack mitoc...

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Literature Corpus work: 824870a4-5199-50b0-ab86-4ab5b2c804ec
DOI: 10.1101/2024.10.02.616229

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