Article

Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency

2022-02-17

Abstract excerpt

<h4>Background: </h4> Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. Wernicke-Korsakoff syndrome (WKS) is a consequence of chronic TD, which leads to extensive neuronal death, and is associated with neuropathological disorders,...

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Literature Corpus work: 822e8d57-1055-5142-83ac-efc95a41a098
DOI: 10.21203/rs.3.rs-1363569/v1

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