Article

Heparanase promotes Syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured <i>ex vivo</i>

2020-06-05

Abstract excerpt

Mammographic density (MD) is a strong and independent factor for breast cancer (BC) risk and is increasingly associated with BC progression. We have previously shown in mice that high MD, which is characterised by the preponderance of a fibrous stroma, facilitates BC xenograft growth and metastasis. This stroma is rich in extracellular matrix (ECM) factors, including heparan sulfate proteoglycans (HSPGs), such as...

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Literature Corpus work: 82285ad3-099f-521e-b1f0-2ebc790d2594
DOI: 10.1101/2020.06.04.135202

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