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Article

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

11 Mar 2014

Abstract excerpt

The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing metastatic potential differ in ECM composition. Both tumor cells and stromal cells contribute to the tumor matrix and tumors of differing metastatic ability differ...

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PMID: 24618895
DOI: 10.7554/elife.01308

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