Article

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

2024-04-19

Abstract excerpt

5-Methylcytosine (m 5 C) is one of the post-transcriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m 5 C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase and reader protein assisted RNA methylation analysis), in which deaminases (APOBEC1...

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Literature Corpus work: 820b37ce-bbbf-578e-bca0-c2d72b730327
DOI: 10.1101/2024.04.17.589933

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