Article

Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments

2024-10-10

Abstract excerpt

Aging is one of the most significant risk factors for breast cancer. With the growing interests in the alterations of the aging breast tissue microenvironment, it has been identified that aging is related to tumorigenesis, invasion, and drug resistance. However, current pre-clinical disease models often neglect the impact of aging and sometimes result in worse clinical outcomes. In this study, we utilized aged ani...

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Literature Corpus work: 85efef0d-44fa-5555-8b86-d14d51f085c7
DOI: 10.1101/2024.10.06.616903

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