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Use of a novel knock-in allele of Pkd1 identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1

2022-04-10

Abstract excerpt

The localization and function of Polycystin-1, the protein encoded by the gene most commonly mutated in autosomal dominant polycystic kidney disease, remains controversial. We have recently reported that its C-terminus is cleaved and traffics to the mitochondria rather than to the nucleus as had been previously described, and we found that absence of PC1 resulted in fragmented mitochondrial networks and increased...

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Literature Corpus work: 81ab19bc-5e45-588d-8089-c7d79354eec0
DOI: 10.1101/2022.04.08.487705

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Use of a novel knock-in allele of Pkd1 identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1DOI 10.1101/2022.04.08.487705Read

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Use of a novel knock-in allele of <i>Pkd1</i> identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1

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