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Article

The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites.

The Journal of biological chemistry - 29 Jul 2011

Barry Amanda N, Otoikhian Adenike, Bhatt Sujata, Shinde Ujwal, Tsivkovskii Ruslan, Blackburn Ninian J, Lutsenko Svetlana

Abstract excerpt

The copper-transporting ATPase ATP7A has an essential role in human physiology. ATP7A transfers the copper cofactor to metalloenzymes within the secretory pathway; inactivation of ATP7A results in an untreatable neurodegenerative disorder, Menkes disease. Presently, the mechanism of ATP7A-mediated copper release into the secretory pathway is not understood. We demonstrate that the characteristic His/Met-rich...

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Identifiers

PMID: 21646353
DOI: 10.1074/jbc.M111.229039
PMCID: PMC3143623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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