Article

GCNA is a histone binding protein required for spermatogonial stem cell maintenance

2022-02-22

Abstract excerpt

Recycling and de-novo deposition of histones during DNA replication is a critical challenge faced by eukaryotic cells and is coordinated by histone chaperones. However, little is known about how tissue-specific histone chaperones function to maintain tissue homeostasis. Here we show that Germ Cell Nuclear Acidic protein (GCNA), a germ cell specific protein in adult mice, can bind histones and purified GCNA exhibi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 818f91c6-177b-5298-83ef-ed339a22a305
DOI: 10.1101/2022.02.21.481287

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GCNA is a histone binding protein required for spermatogonial stem cell maintenanceDOI 10.1101/2022.02.21.481287Read

Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.Semantic proximity Read

SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testisSemantic proximity Read

CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome AssemblySemantic proximity Read

Core binding factor subunit β plays diverse and essential roles in the male germlineSemantic proximity Read

Role of RNA‐binding proteins in mammalian spermatogenesisSemantic proximity Read

Proteomic analysis of male 4C germ cell proteins involved in mouse meiosisSemantic proximity Read

Histone acetylation regulated by histone deacetylases during spermatogenesisSemantic proximity Read

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in MiceSemantic proximity Read

Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairingSemantic proximity Read

The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse.Semantic proximity Read

GCNA preserves genome integrity and fertility across speciesSemantic proximity Read

Heat-shock protein HSPA4 is required for progression of spermatogenesisSemantic proximity Read