Article

Bioinformatic, enzymatic and structural characterization of <i>Trichuris suis</i> hexosaminidase HEX-2

2023-11-16

Abstract excerpt

Hexosaminidases are key enzymes in glycoconjugate metabolism and occur in all kingdoms of life. Here, we have investigated the phylogeny of the GH20 glycosyl hydrolase family in nematodes and identified a β-hexosaminidase subclade only present in the Dorylaimia. We have expressed one of these, HEX-2 from Trichuris suis , a porcine parasite, and shown that it prefers an aryl β- N -acetylgalactosaminide in vitro...

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Literature Corpus work: 81766dbe-a05d-51b0-af5f-67bef11d07f9
DOI: 10.1101/2023.11.15.567194

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