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Article

Biochemical characterization of the endo-α-N-acetylgalactosaminidase pool of the human gut symbiont Tyzzerella nexilis.

Carbohydrate research - 1 Apr 2020

Kulinich Anna, Wang Qian, Duan Xu-Chu, Lyu Yong-Mei, Zhang Xiao-Yang, Awad Faisal Nureldin, Liu Li, Voglmeir Josef

Abstract excerpt

Three large (2084-, 984-, and 2104-amino acids) endo-α-N-acetylgalactosaminidase candidate genes from the commensal human gut bacterium Tyzzerella nexilis were successfully cloned and subsequently expressed in Escherichia coli. Activity tests of the purified proteins revealed that two of the candidate genes (Tn0153 and Tn2105) were able to hydrolyze the disaccharide unit from Galβ1-3GalNAc-α-pNP. The biochemical...

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PMID: 32169671
DOI: 10.1016/j.carres.2020.107962

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