Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Androgen receptor, a possible anti-infective therapy target and a potent immune respondent in SARS-CoV-2 spike binding: a computational approach

9 Feb 2023

Abstract excerpt

BACKGROUND: Although androgen in gender disparity of COVID-19 has been implied, no direct link has been provided. RESEARCH DESIGN AND METHODS: Here, we applied AlphaFold multimer, network and single cells database analyses to highlight specificity of Androgen receptor (AR) against spike receptor binding protein (RBD) of SARS-CoV-2. RESULTS: LXXL motifs in spike RBD are essential for AR binding. RBD LXXA mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36757420
DOI: 10.1080/14787210.2023.2179035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Androgen receptor, a possible anti-infective therapy target and a potent immune respondent in SARS-CoV-2 spike binding: a computational approachPMID 36757420Read ↗

Interaction network of SARS-CoV-2 with host receptome through spike proteinSemantic proximity Read ↗

Structure, function and variants analysis of the androgen-regulated <i>TMPRSS2</i> , a drug target candidate for COVID-19 infectionSemantic proximity Read ↗

Reciprocally Divergent Levels of Testosterone and Dihydrotestosterone Accompany Patterns of Androgen Receptor Pathway Signaling to Dictate COVID-19 Outcomes in MenSemantic proximity Read ↗

Sex-dependent immune response and lethality of COVID-19Semantic proximity Read ↗

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in MenSemantic proximity Read ↗

In Silico Discovery of GPCRs and GnRHRs as Novel Binding Receptors of SARS-CoV-2 Spike Protein Could Explain Neuroendocrine Disorders in COVID-19Semantic proximity Read ↗

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes.Semantic proximity Read ↗

Candidate genes of SARS-CoV-2 gender susceptibility.Semantic proximity Read ↗

Dexamethasone is a gold weapon for immunomodulation in severe COVID-19 but has no effect on endocrine interleukin 6 and sex-linked response the problem – In silico studySemantic proximity Read ↗

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19Semantic proximity Read ↗

Estrogen Hormone Is an Essential Sex Factor Inhibiting Inflammation and Immune Response in COVID-19Semantic proximity Read ↗

The role of andrographolide and its derivative in COVID-19 associated proteins and immune systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.