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Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer.

Chemical research in toxicology - 19 Nov 2012

Coen Muireann, Rademacher Peter M, Zou Wei, Scott Michael, Ganey Patricia E, Roth Robert, Nelson Sidney D

Abstract excerpt

An NMR-based metabonomic approach was applied to study the systems level metabolic effects of two closely related thiophene compounds, tienilic acid (TA) and tienilic acid isomer (TAI). The metabonomic data were anchored with traditional clinical chemistry and histopathologic analyses. TA was removed from the market as a result of suspected immune-mediated hepatotoxicity, whereas TAI is an intrinsic hepatotoxin....

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PMID: 23013248
DOI: 10.1021/tx3002803

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