Back to search

Article

Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer via genomic mechanisms

2020-11-12

Abstract excerpt

Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. Anaplastic thyroid cancer (ATC) is highly aggressive, dedifferentiated, and patients have a median survival of fewer than six months. Oncogenic alterations in ATC include aberrant PI3K signaling through receptor tyrosine kinase (RTK) amplification, loss of phosphoinositide phosphatase e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e5db07fd-5804-5609-ab57-266350f20f66
DOI
10.1101/2020.11.12.379933
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer via genomic mechanismsDOI 10.1101/2020.11.12.379933
Genetic alterations in anaplastic thyroid carcinoma and targeted therapies (Review)Semantic proximity
Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid TumorsSemantic proximity
New Therapies for Advanced Thyroid Cancer.Semantic proximity
Novel targeted therapies and immunotherapy for advanced thyroid cancers.Semantic proximity
PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma.Semantic proximity
The Role of the Kinase Inhibitors in Thyroid CancersSemantic proximity
Clinical and Translational Challenges in Thyroid Cancer.Semantic proximity
Key signaling pathways in thyroid cancerSemantic proximity
Anaplastic thyroid cancer: molecular pathogenesis and emerging therapiesSemantic proximity
Advances in targeted therapy for anaplastic thyroid carcinoma.Semantic proximity
Personalized Therapy in Patients With Anaplastic Thyroid Cancer: Targeting Genetic and Epigenetic AlterationsSemantic proximity
Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid TumorsSemantic proximity
Select a neighboring publication to make it the new centre.