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Article

Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.

The New England journal of medicine - 14 Feb 2013

Ho Alan L, Grewal Ravinder K, Leboeuf Rebecca, Sherman Eric J, Pfister David G, Deandreis Desiree, Pentlow Keith S, Zanzonico Pat B, Haque Sofia, Gavane Somali, Ghossein Ronald A, Ricarte-Filho Julio C, Domínguez José M, Shen Ronglai, Tuttle R Michael, Larson Steve M, Fagin James A

Abstract excerpt

BACKGROUND: Metastatic thyroid cancers that are refractory to radioiodine (iodine-131) are associated with a poor prognosis. In mouse models of thyroid cancer, selective mitogen-activated protein kinase (MAPK) pathway antagonists increase the expression of the sodium-iodide symporter and uptake o...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23406027
DOI: 10.1056/NEJMoa1209288
PMCID: PMC3615415

Genes

NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23406027-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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