Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

Abstract excerpt

Integrating cell type-specific regulatory elements (e.g. enhancers) with recombinant adeno-associated viruses (AAVs) can provide broad and efficient genetic access to specific cell types. However, the packaging capacity of AAVs restricts the size of both the enhancers and the cargo that can be delivered. Transcriptional crosstalk offers a novel paradigm for cell type-specific expression of large cargo, by separati...

Topics

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• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Dependovirus
• DiGeorge Syndrome
• Gene Editing
• Viral Infections and Immunology Research
• Virology and Viral Diseases
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

812c588a-9496-54db-9d43-99583af6b981

DOI

10.1101/2023.12.23.573214