Article

Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements

2020-02-24

Abstract excerpt

In human, execution of unimanual movements requires lateralized activation of the primary motor cortex, which then transmits the motor command to the contralateral hand through the crossed corticospinal tract (CST). Mutations in NETRIN-1 alter motor control lateralization, leading to congenital mirror movements. To address the role of midline Netrin-1 on CST development and subsequent motor control, we analyzed t...

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Literature Corpus work: 81180573-db80-5c65-8fe9-155614f3548d
DOI: 10.1101/2020.02.20.958595

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