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Article

Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior.

Nature communications - 27 Oct 2017

Bocchi Riccardo, Egervari Kristof, Carol-Perdiguer Laura, Viale Beatrice, Quairiaux Charles, De Roo Mathias, Boitard Michael, Oskouie Suzanne, Salmon Patrick, Kiss Jozsef Z

Abstract excerpt

Perturbed neuronal migration and circuit development have been implicated in the pathogenesis of neurodevelopmental diseases; however, the direct steps linking these developmental errors to behavior alterations remain unknown. Here we demonstrate that Wnt/C-Kit signaling is a key regulator of glia-guided radial migration in rat somatosensory cortex. Transient downregulation of Wnt signaling in migrating, callosal...

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Identifiers

PMID: 29079819
DOI: 10.1038/s41467-017-01046-w
PMCID: PMC5660087

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