Article

VPS35 Protects Against TMEM230-Mutation-Induced Progressive Locomotor Deficits in Drosophila

2021-10-26

Abstract excerpt

<title>Abstract</title> <p>BackgroundRecently, four Parkinson’s disease (PD)-linked mutations (<italic>Y92C, R141L, 184PGext*5 and 184Wext*5</italic>) in transmembrane protein 230 (TMEM230) were identified in PD patients, and these mutations have implications in protein trafficking and neurodegeneration. However, there is a lack of in vivo studies on the roles of PD-related variants of <italic>TMEM230</italic> in...

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Literature Corpus work: 810efc6b-9416-5f6b-a245-c792707e93de
DOI: 10.21203/rs.3.rs-952504/v1

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