Article
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport.
Human molecular genetics - 28 Jul 2021
Wang Xiaobo, Guo Gongbo, Zhang Jinru, Aebez Nicolas, Liu Zhaohui, Liu Chun-Feng, Ross Christopher A, Smith Wanli W
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disease with movement disorders including resting tremor, rigidity, bradykinesia and postural instability. Recent studies have identified a new PD associated gene, TMEM230 (transmembrane protein 230). However, the pathological roles of TMEM230 and its variants are not fully understood. TMEM230 gene encodes two protein isoforms. Isoform2 is the major protein form...
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