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Article

Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2016

Hines Elizabeth A, Verheyden Jamie M, Lashua Amber J, Larson Sarah C, Branchfield Kelsey, Domyan Eric T, Gao Juan, Harvey Julie F, Herriges John C, Hu Linghan, Mcculley David J, Throckmorton Kurt, Yokoyama Shigetoshi, Ikeda Akihiro, Xu Guoliang, Sun Xin

Abstract excerpt

BACKGROUND: Fras1 encodes an extracellular matrix protein that is critical for the establishment of the epidermal basement membrane during gestation. In humans, mutations in FRAS1 cause Fraser Syndrome (FS), a pleiotropic condition with many clinical presentations such as limb, eye, kidney, and craniofacial deformations. Many of these defects are mimicked by loss of Fras1 in mice, and are preceded by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26813283
DOI: 10.1002/dvdy.24389
PMCID: PMC4860343

Genes

FRAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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