Article

TRIB2 couples UCP1 degradation to thermogenic adaptation and metabolic health

2025-10-27

Abstract excerpt

Genetic variation in TRIB2 has been associated with thermogenesis and fat accumulation, yet the underlying molecular mechanisms remain unclear. Uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Here, we identified a human TRIB2 variant associated with migration patterns along latitude and environmental temperature, which destabilized its mRNA and is consistent with en...

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Literature Corpus work: 80d88560-17ef-5b41-8cb7-0a40a3dd4315
DOI: 10.1101/2025.10.26.684708

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