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Article

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

The Journal of clinical endocrinology and metabolism - 17 Jun 2026

Gobeil Émilie, Bourgault Jérôme, Gagnon Eloi, Samson Nolwenn, Ruel Louis-Jacques, Côté Valérie, Mitchell Patricia L, Gotti Clarisse, Roux-Dalvai Florence, Droit Arnaud, Bossé Yohan, Mathieu Patrick, Lajeunesse-Trempe Fannie, Vohl Marie-Claude, Caron Alexandre, Tchernof André, Thériault Sébastien, Laplante Mathieu, Arsenault Benoit J

Abstract excerpt

CONTEXT: Genome-wide association studies (GWAS) have identified dozens of genetic loci linked with metabolic dysfunction-associated steatotic liver disease (MASLD). OBJECTIVE: To identify liver-expressed genes that may represent therapeutic candidates for MASLD. METHODS: We conducted a new GWAS meta-analysis including 16 532 cases and 1 240 188 controls. We also generated RNA sequencing data of liver samples and...

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Source

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Identifiers

PMID: 41635218
DOI: 10.1210/clinem/dgag043
PMCID: PMC13271776

Genes

TRIB1
AKNA
CHEK2
EPHA2
PCCB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.PMID 41635218Read ↗

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