Article
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.
Nature communications - 6 Jul 2018
Bricio-Moreno Laura, Sheridan Victoria H, Goodhead Ian, Armstrong Stuart, Wong Janet K L, Waters Elaine M, Sarsby Joscelyn, Panagiotou Stavros, Dunn James, Chakraborty Adrita, Fang Yongliang, Griswold Karl E, Winstanley Craig, Fothergill Joanne L, Kadioglu Aras, Neill Daniel R
Abstract excerpt
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed early-acquired mutations in pmrB, encoding the sensor kinase of a two-component system that promoted establishment and...
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