Article

Human Saposin B Ligand Binding and Presentation to α-Galactosidase A

2024-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular mechanism of SapB presenting Gb3 to α-galactosidase A, we subjected the fluorescent substrate globotriaosylceramide-nitrobenzoxidazole (Gb3-NBD...

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Literature Corpus work: 80a42659-cbb2-5970-83a3-92198741cf6d
DOI: 10.1101/2024.04.04.584535

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