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Article

Catalytic mechanism of human alpha-galactosidase.

The Journal of biological chemistry - 5 Feb 2010

Guce Abigail I, Clark Nathaniel E, Salgado Eric N, Ivanen Dina R, Kulminskaya Anna A, Brumer Harry, Garman Scott C

Abstract excerpt

The enzyme alpha-galactosidase (alpha-GAL, also known as alpha-GAL A; E.C. 3.2.1.22) is responsible for the breakdown of alpha-galactosides in the lysosome. Defects in human alpha-GAL lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of alpha-galactosylated substrates in the tissues. alpha-GAL is an active target of clinical research: there are currently two...

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Source

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Identifiers

PMID: 19940122
DOI: 10.1074/jbc.M109.060145
PMCID: PMC2823503

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Efficient and rapid purification of recombinant human alpha-galactosidase A by affinity column chromatography.Semantic proximity Read ↗

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Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.Semantic proximity Read ↗

Maturation of Lysosomal α-Galactosidase A and Implications for Fabry Disease.Semantic proximity Read ↗

Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate.Semantic proximity Read ↗

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