Article

Multi-omics and spatial analysis of microgravity-grown glioblastoma organoids reveals superior modeling of advanced disease after long-term spaceflight

2026-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is an incurable brain cancer characterized by its highly immunosuppressive tumor microenvironment and aggressive malignant features that resist treatment. To overcome limitations of Earth-based models (sedimentation and disaggregation) and leverage the unique biological effects of space (accelerated disease progression and immune dysregulation), we developed a panel of GBM-mye...

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Literature Corpus work: 807982de-bb5f-583c-8e46-9afda1c46d79
DOI: 10.64898/2026.03.06.710192

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