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Spatial analysis of the glioblastoma proteome reveals specific molecular signatures and markers of survival

4 Nov 2022

Abstract excerpt

Molecular heterogeneity is a key feature of glioblastoma that impedes patient stratification and leads to large discrepancies in mean patient survival. Here, we analyze a cohort of 96 glioblastoma patients with survival ranging from a few months to over 4 years. 46 tumors are analyzed by mass spectrometry-based spatially-resolved proteomics guided by mass spectrometry imaging. Integration of protein expression...

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PMID: 36333286
DOI: 10.1038/s41467-022-34208-6

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