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Postmortem Diagnosis of Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Metastatic NTRK Gene Fusion-Positive Transverse Colon Cancer During Effective Entrectinib Treatment

2025-07-30

Abstract excerpt

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare but fatal malignancy-related complication characterized by tumor embolization in small pulmonary arteries, leading to acute respiratory failure and pulmonary hypertension. Neurotrophic tropomyosin receptor kinase (NTRK) gene fusion-positive colorectal cancer (CRC) is resistant to conventional chemotherapy but responds to tropomyosin receptor kinase (TRK)...

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Literature Corpus work
8074f67a-33d3-5a51-a206-0b945c761832
DOI
10.20944/preprints202507.2557.v1
Open publication

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Postmortem Diagnosis of Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Metastatic NTRK Gene Fusion-Positive Transverse Colon Cancer During Effective Entrectinib TreatmentDOI 10.20944/preprints202507.2557.v1
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