Article

Epigenetic regulation of protein translation in <i>KMT2A</i> -rearranged AML

2019-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of the histone methyl-transferase DOT1L (KMT4) has shown encouraging activity in preclinical models of KMT2A ( MLL) -rearranged leukemia. The DOT1L inhibitor pinometostat (EPZ5676) was well tolerated in early phase clinical trials and showed modest clinical activity, including occasional complete responses (CRs) as single agent. These studies support the development of combinatorial...

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Literature Corpus work: 806f1b27-4058-5f9f-ab32-3c079bc1fdfe
DOI: 10.1101/790287

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