Article
Optimization of virulence functions through glucosylation of Shigella LPS.
Science (New York, N.Y.) - 25 Feb 2005
West Nicholas P, Sansonetti Philippe, Mounier Joëlle, Exley Rachel M, Parsot Claude, Guadagnini Stéphanie, Prévost Marie-Christine, Prochnicka-Chalufour Ada, Delepierre Muriel, Tanguy Myriam, Tang Christoph M
Abstract excerpt
Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes,...
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